9gnn

Structural highlights

Function

SENP5_HUMAN Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.^{[1] [2]}

References

1. ↑ Gong L, Yeh ET. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun 9;281(23):15869-77. PMID:16608850 doi:10.1074/jbc.M511658200
2. ↑ Di Bacco A, Ouyang J, Lee HY, Catic A, Ploegh H, Gill G. The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol. 2006 Jun;26(12):4489-98. PMID:16738315 doi:10.1128/MCB.02301-05