9hju

Structural highlights

Function

ZFP91_HUMAN Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.^{[1] [2]}

References

1. ↑ Unoki M, Okutsu J, Nakamura Y. Identification of a novel human gene, ZFP91, involved in acute myelogenous leukemia. Int J Oncol. 2003 Jun;22(6):1217-23. PMID:12738986
2. ↑ Jin X, Jin HR, Jung HS, Lee SJ, Lee JH, Lee JJ. An atypical E3 ligase zinc finger protein 91 stabilizes and activates NF-kappaB-inducing kinase via Lys63-linked ubiquitination. J Biol Chem. 2010 Oct 1;285(40):30539-47. doi: 10.1074/jbc.M110.129551. Epub 2010, Aug 3. PMID:20682767 doi:10.1074/jbc.M110.129551