Structural highlights
Function
CIRCN_BPMU Required for tail assembly of phage Mu and responsible for circularizing the viral DNA after it has been ejected into the host cell. Following infection, the circularized DNA can be isolated as a supercoiled, non-covalent protein-DNA complex, in which the protein N is bound to the ends of the DNA. Protects linear double-stranded DNA of viral genome from host exonuclease degradation.[1] [2] [3]
References
- ↑ Puspurs AH, Trun NJ, Reeve JN. Bacteriophage Mu DNA circularizes following infection of Escherichia coli. EMBO J. 1983;2(3):345-52. PMID:11894948 doi:10.1002/j.1460-2075.1983.tb01429.x
- ↑ Gloor G, Chaconas G. The bacteriophage Mu N gene encodes the 64-kDa virion protein which is injected with, and circularizes, infecting Mu DNA. J Biol Chem. 1986 Dec 15;261(35):16682-8 PMID:3023361
- ↑ Harshey RM, Bukhari AI. Infecting bacteriophage mu DNA forms a circular DNA-protein complex. J Mol Biol. 1983 Jun 25;167(2):427-41. PMID:6306260 doi:10.1016/s0022-2836(83)80343-x
