9mhp

Structural highlights

Function

TOM1_YEAST Probable ubiquitin ligase protein involved in many cellular processes, such as transcription regulation, maintenance of nuclear structure, cell cycle, mRNA export and rRNA maturation. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Involved in transcription regulation by interacting, and probably mediating, ubiquitination of some subunit of the SAGA complex. Required for SPT7 ubiquitination. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins. Required for the shuttling of hnRNP protein NAB2, probably by mediating ubiquitination of a protein associated with NAB2. Also required for full induction of the general stress and heat-shock responses. Involved in 18S rRNA maturation by affecting several early steps in the rRNA processing pathway.^{[1] [2] [3] [4] [5]}

References

1. ↑ Utsugi T, Hirata A, Sekiguchi Y, Sasaki T, Toh-e A, Kikuchi Y. Yeast tom1 mutant exhibits pleiotropic defects in nuclear division, maintenance of nuclear structure and nucleocytoplasmic transport at high temperatures. Gene. 1999 Jul 8;234(2):285-95. PMID:10395901 doi:10.1016/s0378-1119(99)00197-3
2. ↑ Sasaki T, Toh-e A, Kikuchi Y. Extragenic suppressors that rescue defects in the heat stress response of the budding yeast mutant tom1. Mol Gen Genet. 2000 Jan;262(6):940-8. PMID:10660055 doi:10.1007/pl00008662
3. ↑ Duncan K, Umen JG, Guthrie C. A putative ubiquitin ligase required for efficient mRNA export differentially affects hnRNP transport. Curr Biol. 2000 Jun 15;10(12):687-96. PMID:10873801 doi:10.1016/s0960-9822(00)00527-3
4. ↑ Tabb AL, Utsugi T, Wooten-Kee CR, Sasaki T, Edling SA, Gump W, Kikuchi Y, Ellis SR. Genes encoding ribosomal proteins Rps0A/B of Saccharomyces cerevisiae interact with TOM1 mutants defective in ribosome synthesis. Genetics. 2001 Mar;157(3):1107-16. PMID:11238398 doi:10.1093/genetics/157.3.1107
5. ↑ Saleh A, Collart M, Martens JA, Genereaux J, Allard S, Cote J, Brandl CJ. TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes. J Mol Biol. 1998 Oct 9;282(5):933-46. PMID:9753545 doi:10.1006/jmbi.1998.2036