9uhd

Structural highlights

Function

CBAR1_MOUSE Plays a critical role in regulating mitochondrial ultrastructure and function by maintaining the integrity of mitochondrial morphology, particularly the organization of cristae (By similarity). Preferentially binds to negatively charged phospholipids like cardiolipin and phosphatidylinositol 4,5-bisphosphate enhancing its interaction with mitochondrial membranes (By similarity). Induces membrane curvature and tubulation, which are critical for maintaining mitochondrial ultrastructure and the organization of cristae (By similarity). Plays a crucial role in ciliogenesis (PubMed:29459677). May play a role in limb development through its role in ciliogenesis (PubMed:30395363). Plays a key role in the correct positioning of the annulus, a septin-based ring structure in the sperm flagellum, serving both as a physical barrier and a membrane diffusion barrier that separates the midpiece (MP) from the principal piece (PP) (PubMed:38197861). This positioning is essential for proper sperm motility and function (PubMed:38197861). Interacts with CBY3 to form a complex which localizes to the curved membrane region of the flagellar pocket (PubMed:38197861). By doing so, may provide stability and rigidity to the periannular membrane to prevent membrane deformation (PubMed:38197861). This function is crucial for halting annulus migration at the proximal end of the fibrous sheath-containing PP (PubMed:38197861).[UniProtKB:A1XBS5]^{[1] [2] [3]}

References

1. ↑ Breslow DK, Hoogendoorn S, Kopp AR, Morgens DW, Vu BK, Kennedy MC, Han K, Li A, Hess GT, Bassik MC, Chen JK, Nachury MV. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Nat Genet. 2018 Mar;50(3):460-471. PMID:29459677 doi:10.1038/s41588-018-0054-7
2. ↑ Schrauwen I, Giese AP, Aziz A, Lafont DT, Chakchouk I, Santos-Cortez RLP, Lee K, Acharya A, Khan FS, Ullah A, Nickerson DA, Bamshad MJ, Ali G, Riazuddin S, Ansar M, Ahmad W, Ahmed ZM, Leal SM. FAM92A Underlies Nonsyndromic Postaxial Polydactyly in Humans and an Abnormal Limb and Digit Skeletal Phenotype in Mice. J Bone Miner Res. 2019 Feb;34(2):375-386. PMID:30395363 doi:10.1002/jbmr.3594
3. ↑ Hoque M, Li FQ, Weber WD, Chen JJ, Kim EN, Kuo PL, Visconti PE, Takemaru KI. The Cby3/ciBAR1 complex positions the annulus along the sperm flagellum during spermiogenesis. J Cell Biol. 2024 Mar 4;223(3):e202307147. PMID:38197861 doi:10.1083/jcb.202307147