Chloramphenicol acetyltransferase

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Contents

Function

Chloramphenicol acetyltransferase (CAT) is an enzyme which makes bacteria resistant to chloramphenicol. It attaches acetyl from acetyl-CoA to chloramphenicol thus preventing it from binding to the ribosome. [1] Additional details in Chloramphenicol Acetyltransferase Type III.

Structural highlights

E. coli chloramphenicol acetyltransferase III is homotrimer. In CAT III chloramphenicol binds in a deep pocket at the interface of 2 subunits (PDB entry 3cla).[1] Water molecules are shown as red spheres.

3D Structures of Chloramphenicol acetyltransferase

Chloramphenicol acetyltransferase 3D structures


E. coli chloramphenicol acetyltransferase III complex with chloramphenicol and Co+2 ions (PDB entry 3cla)

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References

  1. 1.0 1.1 Leslie AG. Refined crystal structure of type III chloramphenicol acetyltransferase at 1.75 A resolution. J Mol Biol. 1990 May 5;213(1):167-86. PMID:2187098

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