DNA methyltransferase 3D structures

1qnt, 1eh6, 3llr - hO6-methylguanine DNMT – human

1t38 - hO6-methylguanine DNMT (mutant) + DNA

1t39, 1yfh - hO6-methylguanine DNMT + DNA

1eh7 - hO6-methylguanine DNMT methylated

1eh8 - hO6-methylguanine DNMT benzylated

1mgt - O6-methylguanine DNMT – Thermococcus kodakarensis

1wrj, 7dkn - O6-methylguanine DNMT - Sulfolobus tokodaii

7csm, 7d4v, 7dqr, 7dqt - StO6-methylguanine DNMT (mutant)

7e1p - StO6-methylguanine DNMT (mutant) + purine derivative

7dqq - StO6-methylguanine DNMT (mutant) + methyldeoxyguanosine

2g7h - O6-methylguanine DNMT – Methanocaldococcus jannaschii

2kif, 2kim - O6-methylguanine DNMT – Vibrio parahaemolyticus - NMR

4bhb, 4bhc, 4wxd, 4wxc - MtO6-methylguanine DNMT (mutant) – Mycobacterium tuberculosis

4wx9 - MtO6-methylguanine DNMT (mutant) + modified DNA

4zyg, 4zye, 6ga0 - SsO6-methylguanine DNMT – Sulfolobus solfataricus

5llq, 4zyh - SsO6-methylguanine DNMT (mutant)

4zyd - SsO6-methylguanine DNMT (mutant) + modified DNA

1sfe – O6-methylguanine DNMT C terminal – Escherichia coli

8v9u - h-cytosine DNMT 1 N-terminal domain - NMR

3epz - h-cytosine DNMT 1 RFTS domain

1g55 - h-cytosine DNMT 2 (mutant)

2qrv - h-cytosine DNMT 3A C-terminal domain

3a1a, 8ba5 - h-cytosine DNMT 3A ADD domain

8tdr - h-cytosine DNMT 3A methyltransferase domain

8te1, 8te3, 8te4 - h-cytosine DNMT 3A methyltransferase domain (mutant)

7v0e - h-cytosine DNMT 3B methyltransferase domain

7o45 - h-cytosine DNMT 3B ADD domain

3flg, 8zlk, - h-cytosine DNMT 3B PWWP domain

3qkj - h-cytosine DNMT 3B residues 293-442

3av4, 1khc - m-cytosine DNMT residues 291-1620 – mouse

5wy1 - m-cytosine DNMT (mutant)

5guv, 5gut - m-cytosine DNMT residues 731-1600 (mutant)

1boo - cytosine DNMT (mutant) – Proteus vulgaris

1svu - Hh-cytosine DNMT (mutant) - Haemophilus haemolyticus

4h0n - cytosine DNMT (mutant) – Spodoptera frugiperda

6pa7 - h-cytosine DNMT 3A residues 224-912 + h-cytosine DNMT 3B residues 1-770 + SAH + histones + DNA – Cryo EM

6w89, 6w8b, 6w8d, 6w8j - h-cytosine DNMT 3A residues 628-912 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor

6f57, 5yx2 - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative

6brr - h-cytosine DNMT 3A residues 439-723 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH + pyrimidine derivative

6w8b - h-cytosine DNMT 3A residues 628-912 + h-cytosine DNMT 3L residues 178-379 + DNA + SAH

6kda, 6kdb, 6kdl - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH

6u8p, 6u8v, 6u8x - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor

6u8w, 6u90, 6u91 - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + DNA + SAH + inhibitor

6w8v, 6w8w - m-cytosine DNMT1 residues 731-1600 + SAH + DNA

3pt6, 3pt9, 4da4 – m-cytosine DNMT residues 650-1602 + DNA

2uyc, 2uyh, 2uz4, 1fjx – Hh-cytosine DNMT (mutant) + DNA + SAH

2c7o, 2c7p, 2c7q, 2c7r, 3pta, 4da4 – Hh-cytosine DNMT + DNA + SAH

1m0e - Hh-cytosine DNMT (mutant) + DNA + inhibitor

2i9k – Hh-cytosine DNMT (mutant) + DNA

2hr1 - Hh-cytosine DNMT + DNA + ADOHCY

2z6q, 2z6u, 2zcj - Hh-cytosine DNMT (mutant) + DNA + ADOHCY

4yoc - h-cytosine DNMT 1 residues 600-1600 + ubiquitin carboxyl-terminal hydrolase 7

4z97, 4z96 - h-cytosine DNMT 1 residues 1097-1129 + ubiquitin carboxyl-terminal hydrolase 7

5ydr - h-cytosine DNMT 1 RFTS domain + ubiquitin

5wvo - h-cytosine DNMT 1 RFTS domain + ubiquitin + histone H3.1

8xqc - h-cytosine DNMT 1 351-1616 + ubiquitin + PAF15 + DNA – Cryo EM

7xi9 – hDNMT 1 351-1600 + H3 – Cryo EM

3a1b, 4qbq - h-cytosine DNMT 3A ADD domain + histone H3

4qbr, 4qbs - h-cytosine DNMT 3A ADD domain (mutant) + histone H3

4u7t - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + histone 3.3 peptide + SAH

8uw1 - h-cytosine DNMT 3A residues 159-228 in nucleosome – Cryo EM

5ciu, 5ciy - h-cytosine DNMT 3B PWWP domain + histone H3.2

6pzv – b-cytosine DNMT 1 RFTS domain + histone H3.3 + ubiquitin - bovine

7lmk, 7lmm – b-cytosine DNMT 1 BAH1 domain + histone H4

4ft2, 4ft4 – c-cytosine DNMT + histone H3 peptide – corn

4wxx - h-cytosine DNMT 1 residues 351-1600 + SAH

7sfc, 7sfd, 7sfe, 7sff, 7sfg – hDNMT 1 729-1600 + DNA + CMP + pyrimidine derivative + SAM

6x9j, 6x9k, 6x9i – hDNMT 1 729-1600 + DNA + CMP + pyrimidine derivative + SAH

7xi9 – hDNMT 1 351-1600 + H3 – Cryo EM

4u7p - h-cytosine DNMT 3A residues 455-912 + h-cytosine DNMT 3L residues 178-379 + SAH

5nvo - h-cytosine DNMT 3B PWWP domain + choline

5nv7, 5nv2, 5nv0, 5nrv, 5nrs, 5nrr, 5nr3, 6r3e - h-cytosine DNMT 3B PWWP domain + inhibitor

6kdp - h-cytosine DNMT 3B residues 563-853 + h-cytosine DNMT 3L residues 178-386 + SAH

6kdt - h-cytosine DNMT 3B residues 563-853 (mutant) + h-cytosine DNMT 3L residues 178-386 + SAH

8eih, 8eii, 8eij, 8eik - h-cytosine DNMT 3B residues 206-853 + SAH – Cryo EM

7x9d - h-cytosine DNMT 3B residues 571-853 + harmine

8xee - h-cytosine DNMT 3B residues 571-853 (mutant) + SAH

3swr - h-cytosine DNMT + sinefungin

6w8v, 6w8w - m-cytosine DNMT1 residues 731-1600 + SAH + CMP derivative

3av5 - m-cytosine DNMT residues 291-1620 + SAH

3av6 - m-cytosine DNMT residues 650-1620 + SAM

4fsx – c-cytosine DNMT + SAH

3qv2 - cytosine DNMT + SAH – Entamoeba histolytica<br />

1hmy – HhHaeiii DNMT + SAM

6ped – hN6AMT1 + tRNA methyltransferase

6h1d – hN6AMT1 + TRMT112

6kmr, 6kms – hN6AMT1 + TRMT112 + SAM

6h1e – hN6AMT1 + TRMT112 + SAH + histone H4 peptide

6khs – hN6AMT1 + TRMT112 + SAH + methylGln

1nw5 – RsN6-adenine DNMT + SAM – Rhodobacter sphaeroides

1nw6 - RsN6-adenine DNMT + sinefungin

1nw7 - RsN6-adenine DNMT + SAH

1nw8 - RsN6-adenine DNMT (mutant)

5hek - HpN6-adenine DNMT – Helicobacter pylori

5hfj, 6k0x - HpN6-adenine DNMT + sinefungin

2ibs, 2ibt, 2ih2, 2ih4, 2ih5, 2np6, 2np7, 1g38 - Ta-adenine DNMT Taqi + DNA + cofactor analog – Thermus aquaticus

1aqi – Ta-adenine DNMT Taqi + SAH

1aqj – Ta-adenine DNMT Taqi + sinefungin

2adm - Ta-adenine DNMT Taqi + SAM

1g60 - adenine DNMT + SAM – Moraxella bovis

4rtj, 4rtl, 4rto - Ec-adenine DNMT + DNA + sinefungin

4rtk - Ec-adenine DNMT + DNA + SAH

4gbe - Ec-adenine DNMT + SAH

4gol, 4gom, 4gon, 4goo - Ec-adenine DNMT + SAM derivative

4rtm, 4rtp, 4rtr, 4rts - Ec-adenine DNMT + DNA + AdoMet

4rtn, 4rtq - Ec-adenine DNMT + DNA + AdoHcy

7m6b - adenine DNMT + SAM + SAH – Caldicellulosiraptor bescii

7lni, 7lnj – Cd-adenine DNMT + DNA – Clostridioides difficile

7lnj, 7lt5 – Cd-adenine DNMT + DNA + SAH

7rfk, 7rfl, 7rfm, 7rfn, 8cy2, 8fs1, 8fs2 – Cd-adenine DNMT + DNA + inhibitor

8cxs, 8cxt, 8cxu, 8cxv, 8cxw, 8cxx, 8cxy, 8cxz, 8cy0, 8cy1, 8cy2j, 8cy3, 8cy4, 8cy5 – Cd-adenine DNMT + DNA + inhibitor

7lo5, 7lvv - adenine DNMT + DNA + SAM – Deinococcus wulumuquiensis – Cryo EM

7qw5, 7qw6, 7qw7, 7qw8 – adenine DNMT + DNA + SAH – Geobacillus stearothermophilus

7vru, 7vs4 – adenine DNMT + DNA + AMP + SAH – Pseudomonas alcaligenes

8q56 – adenine DNMT + OCR + SAM – Salmonella enterica

5lod – HhHDMT

1fjx, 2hmy – HhHDMT + SAM – Haemophilus haemolyticus

1svu – HhHDMT (mutant) + SAH

1hmy, 1mht, 3mht, 4mht, 5mht, 7mht, 8mht, 2hr1, 3eeo – HhHDMT + DNA + SAH

2i9k, 2z6a, 2z6u, 2zcj – HhHDMT (mutant) + DNA + SAH

6mht – HhHDMT + DNA + SAH + thiodeoxycytidine

9mht – HhHDMT + DNA + SAH + abasic dideoxyribose

1skm – HhHDMT + DNA + SAH + bicyclohexane

10mh – HhHDMT + DNA + SAH + dihydroazacytosine

1m0e – HhHDMT + DNA + SAH + zebularine

2c7o, 2c7p, 2c7q – HhHDMT + DNA + SAH + methyl cytosine + aminopurine

2c7r – HhHDMT (mutant) + DNA + SAH + methyl cytosine + aminopurine

2z6q – HhHDMT (mutant) + DNA + SAH + deoxycytidine

2uyc, 2uyh, 2uz4 – HhHDMT (mutant) + DNA + SAH + methyl cytosine

4onj – tHDMT catalytic domain + sinefungin – tobacco

4onq – tHDMT catalytic domain (mutant) + sinefungin