Function
Coagulation factor XII (FXII) or Hageman factor is the zymogen of factor XIIa (FXIIa). Factor XIIa , the active form of factor XII, is of crucial importance in fibrin formation[1] and initiates the procoagulant and proinflammatory contact system.
Disease
FXIIa has critical role in coagulation in thromboembolic diseases.
Relevance
Inhibition of the FXII-driven contact system may be a promising therapeutic anticoagulation treatment strategy[2]. The choice of cyclic peptides as inhibitors of FXIIa is based on their being cell-permeable and more stable to proteolysis.
Structural highlights
The 3D structure of the complex between human FXIIa and a cyclic peptide inhibitor[3] shows the peptide forming . Contacting residues of human FXIIa and cyclic peptide inhibitor are shown at ball-and-stick representation and colored deep sky blue and green, respectively. of the complex between human FXIIa and a cyclic peptide inhibitor.
FXII 3D structures
3D structures of FXII
