MTOR signaling pathway

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mTOR (mammalian target of Rapamycin) integrates the input from insulin, growth factors and amino acids. Rapamycin inhibits mTOR by association with FKBP12[1]. mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.


Rapamycin in complex with two protein fragments, the PPIase domain of FKBP52 and the FRB fragment of mTOR (PDB ID 4drj).
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References

  1. ↑ Laplante M, Sabatini DM. mTOR signaling in growth control and disease. Cell. 2012 Apr 13;149(2):274-93. doi: 10.1016/j.cell.2012.03.017. PMID:22500797 doi:http://dx.doi.org/10.1016/j.cell.2012.03.017

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Alexander Berchansky

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