Monomethylamine methyltransferase

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Function

Monomethyamine methyltransferase (MtmB) initiates methanogenesis from mono-, di- and trimethylamines. The genes contain a UAG codon which is decoded by a special tRNA as Pyrrolysine. The pyrrolysine activates and optimally orients methylamine for methyl transfer[1]. Pyrrolysine is considered as the 22st amino acid.

Structural highlights

Pyrrolysine, encoded by the UAG codon is observed in the active site of MtmB[2].

3D structures of monomethyamine methyltransferase

Monomethyamine methyltransferase 3D structures

MtmB complex with pyrrolysine (PDB code 1l2q)

Drag the structure with the mouse to rotate

References

  1. Krzycki JA. Function of genetically encoded pyrrolysine in corrinoid-dependent methylamine methyltransferases. Curr Opin Chem Biol. 2004 Oct;8(5):484-91. doi: 10.1016/j.cbpa.2004.08.012. PMID:15450490 doi:http://dx.doi.org/10.1016/j.cbpa.2004.08.012
  2. Hao B, Gong W, Ferguson TK, James CM, Krzycki JA, Chan MK. A new UAG-encoded residue in the structure of a methanogen methyltransferase. Science. 2002 May 24;296(5572):1462-6. PMID:12029132 doi:10.1126/science.1069556

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Michal Harel

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