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Neurotrophin

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Glycosylated human NT3 homodimer (cyan and green) complex with p75NTR (pink and yellow) (PDB code 3buk)

Drag the structure with the mouse to rotate

3D structures of neurotrophin

Updated on 01-January-2019

1b8k, 1nt3 – hNT3 – human
3buk – hNT3 + P75NTR
1bnd – hNT3 139-257 + BDNF
1b98 – hNT4 81-210
1b8m, 1hcf – hNT4 81-210 + BDNF

References

  1. Facci L, Skaper SD. Culture of rat cerebellar granule neurons and application to identify neuroprotective agents. Methods Mol Biol. 2012;846:23-37. doi: 10.1007/978-1-61779-536-7_3. PMID:22367798 doi:http://dx.doi.org/10.1007/978-1-61779-536-7_3
  2. Chao MV, Rajagopal R, Lee FS. Neurotrophin signalling in health and disease. Clin Sci (Lond). 2006 Feb;110(2):167-73. doi: 10.1042/CS20050163. PMID:16411893 doi:http://dx.doi.org/10.1042/CS20050163
  3. Gong Y, Cao P, Yu HJ, Jiang T. Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex. Nature. 2008 Aug 7;454(7205):789-93. Epub 2008 Jul 2. PMID:18596692 doi:10.1038/nature07089

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