SUMO conjugating enzyme Ubc9

From Proteopedia

Function SUMO conjugating enzyme Ubc9 accepts the ubiquitin-like SUMOs and catalyzes their attachment to other proteins with the help of E3 ligase[1]. Relevance Ubc9 inhibitors may be therapeutic agents against fibrotic diseases like rheumatoid arthritis[2][3].

spinqualitylabelsall models SUMO conjugating enzyme Ubc9 tetramer 2gjd Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of SUMO conjugating enzyme Ubc9

Updated on 10-December-2023

Ubc9

1a3s - hUbc9 - human

5f6e – hUbc9 (mutant)

1u9a - mUbc9 - mouse

1u9b - mUbc9 (mutant)

2gjd – yUbc9 - yeast

4jue, 4m1n – Ubc9 – Plasmodium falciparum

Ubc9 complexes

2xwu – hUbc9+importin13

2px9 – hUbc9+SUMO2

2pe6, 8odr - hUbc9+SUMO1

4y1l – hUbc9 + RSUME

6q83 – hUbc9 + KAP122

6syf – hUbc9 + peptide

5f6d, 5f6u, 5f6v, 5f6w, 5f6x, 5f6y – hUbc9 (mutant) + inhibitor

2o25, 2px9 - hUbc9+ ubiquitin-conjugating enzyme E1

2grn - hUbc9+ RAN GTPase activating protein 1 C-terminal

1kps - hUbc9+ RAN GTPase activating protein 1

1z5s - hUbc9+ RAN GTPase activating protein 1 C-terminal+SMT3C+RAN-binding protein 2

3uin, 3uio, 3uip - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + RANBP2

4w5v, 5fq2 - hUbc9+ SUMO activating enzyme

5d2m - hUbc9+ RAN GTPase activating protein 1 + SUMO2 + ZNF451

2gro, 2grp, 2grq, 2grr - hUbc9 (mutant)+ RAN GTPase activating protein 1 C-terminal

3a4s – hUbc9 + NFATC2-interacting protein ubiquitin-like domain

2vrr, 2uyz – mUbc9+SUMO1

3ong, 3onh – yUbc9+ubiquitin-conjugating enzyme E1-like

2eke – yUbc9+SMT3

5jne – yUbc9 + SMT3 + PCNA + SIZ1

7p47 – yUbc9 + SMT3 + MMS21 + SMC5

3rcz – Ubc9 + DNA repair protein SUMO-like domain – fission yeast

References

1. ↑ Klug H, Xaver M, Chaugule VK, Koidl S, Mittler G, Klein F, Pichler A. Ubc9 sumoylation controls SUMO chain formation and meiotic synapsis in Saccharomyces cerevisiae. Mol Cell. 2013 Jun 6;50(5):625-36. doi: 10.1016/j.molcel.2013.03.027. Epub 2013, May 2. PMID:23644018 doi:http://dx.doi.org/10.1016/j.molcel.2013.03.027
2. ↑ Khodzhigorova A, Distler A, Lang V, Dees C, Schneider H, Beyer C, Gelse K, Distler O, Schett G, Distler JH. Inhibition of sumoylation prevents experimental fibrosis. Ann Rheum Dis. 2012 Nov;71(11):1904-8. doi: 10.1136/annrheumdis-2012-201746. Epub, 2012 Aug 17. PMID:22904261 doi:http://dx.doi.org/10.1136/annrheumdis-2012-201746
3. ↑ Li F, Li X, Kou L, Li Y, Meng F, Ma F. SUMO-conjugating enzyme UBC9 promotes proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis. Inflammation. 2014 Aug;37(4):1134-41. doi: 10.1007/s10753-014-9837-x. PMID:24531852 doi:http://dx.doi.org/10.1007/s10753-014-9837-x