Salt bridge

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Salt bridges are ionic interactions between oppositely charged side chains in proteins. Sometimes, interactions between charged side chains and bound ions are also call salt bridges. The strength of a salt bridge is strongly dependent on the chemical environment (solvent exposed or buried, nature of the solvent). The contribution of salt bridges to the folded state of the protein is complicated [1].

Examples

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References

  1. ↑ Hendsch ZS, Tidor B. Do salt bridges stabilize proteins? A continuum electrostatic analysis. Protein Sci. 1994 Feb;3(2):211-26. doi: 10.1002/pro.5560030206. PMID:8003958 doi:http://dx.doi.org/10.1002/pro.5560030206
  2. ↑ Donald JE, Kulp DW, DeGrado WF. Salt bridges: geometrically specific, designable interactions. Proteins. 2011 Mar;79(3):898-915. doi: 10.1002/prot.22927. Epub 2011 Jan 5. PMID:21287621 doi:http://dx.doi.org/10.1002/prot.22927

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Karsten Theis

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