1ACJ shows the crystal structure of Torpedo californica acetylcholinesterase (TcAChE) complexed with tacrine.
Tacrine is a reversible inhibitor of cholinesterase. It was the first FDA approved drug for the treatment of Alzheimer's disease.
Tacrine’s ring is between the aromatic rings of tryptophan 84 and phenylalanine 330 (W84 and F330).
You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue.
Function
has no known function
Disease
Relevance
Structural highlights
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