Thymidylate synthase 3D structures

From Proteopedia

3D structures of thymidylate synthase

Updated on 25-December-2023 - For a general description of the protein see Thymidylate synthase

Thymidylate synthase

1hw3, 1hw4, 1hzw, 1ypv, 2onb, 4gyh, 4h1i, 4up1, 5x5a, 5x693n5g, 4kpw - hTS – human

2rd8, 2rda, 3egy, 3ehi, 3eaw, 3ebu, 3ed7, 3edw, 3ef9, 3ejl, 3gg5, 3gh0, 3gh2, 4jef, 4o1u, 4o1x, 5x4w, 5x4x, 5x4y, 6qyq – hTS (mutant)

3ihi – mTS – mouse

4iqb – nTS – nematode

6k7q – sTS - shrimp

3tms, 1tjs, 1f4b, 2ftq – EcTS – Escherichia coli

1ajm, 1bq2, 1qqq, 1ev5, 1ev8, 1evf, 1evg, 1ffl, 2g8x, 2ftn - EcTS (mutant)

4tms, 1tda - LcTS – Lactobacillus casei

1tsw, 1tsz - LcTS (mutant)

1tis – TS – Enterobacteria phage T4

1bsf, 1bko, 1bkp, 1bsp - BsTS - Bacillus subtilis

3ix6 – BmTS – Brucella melitensis

3kgb – TS – Encephalitozoon cuniculi

3v8h – TS – Burkholderia thailandensis

4h0r - CgTS – Corynebacterium glutamicum

7ta9 – TS – Acinetobacter baumannii

4xse - VvTS – Varicella-zoster virus

6auj - TS – Elizabethkingia anophelis

7cc8 - wssvTS – white spot syndrome virus

5h38 – hhvORF70 – human herpesvirus 8

Thymidylate synthase binary complex with UMP

6qsh - hTS + dUMP

3hb8 - hTS (mutant) + UMP

6qxg - hTS + fluoro-dUMP

3h9k - hTS (mutant) + fluoro-dUMP

4e5o - mTS + UMP

4irr, 4isw – nTS + UMP

5by6 – TwTS + UMP – Trichina worm

6k7r – sTS + UMP

1tdc, 1thy, 2tdm, 5x5d – LcTS + UMP

1tsv, 1tsx, 1tsy, 1njd, 1njb, 1vza, 1vzb, 1jmf, 1jmg, 1jmh, 1jmi, 1bo7, 1bo8, 1bp6, 1bpj, 1bp0, 2g86, 2g89, 2g8a, 2g8d - LcTS (mutant) + UMP

1tdb - LcTS + fluoro-UMP

1vzc - LcTS (mutant) + fluoro-UMP

1bid - EcTS + UMP

2vet - EcTS (mutant) + UMP

3b9h - EcTS + nitro-UMP

3bfi - EcTS (mutant) + nitro-UMP

4dq1 - TS + UMP – Staphylococcus aureus

6qya – EfTS + dUMP – Enterococcus faecalis

4foa - MtTS + fluoro-UMP – Mycobacterium tuberculosis

4h0u – CgTS + UMP

7dp6 – BmaTS (mutant) + UMP – Brugia malayi

4xsc - VvTS + d-Uridine derivative

4xsd - VvTS + dUMP

5h39 – hhvORF70 + UMP

7xyj – wssvORF70 + UMP

Thymidylate synthase binary complex without UMP

5wrn - hTS + CMP

3ob7 - hTS (mutant) + glutathione

4g2o – hTS (mutant) + purpurogallin

4gd7 – hTS + purpurogallin

4g6w – hTS (mutant) + bromobenzine-triol

3n5e, 4fgt - hTS + peptide inhibitor

4e28 - hTS + inhibitor

6r2e – hTS (mutant) + folate derivative

4ein – mTS + substrate analog

6gyj - mTS + phenolphthalein

4psg – nTS + inhibitor

1tmk - TS + TMP – yeast

1nje - LcTS + CMP

1nja, 1njc - LcTS (mutant) + CMP

1tsl, 1tsm - LcTS + inhibitor

4tmk, 5tmp, 1an5 - EcTS + inhibitor

1fwm - EcTS (mutant) + inhibitor

1aob, 1bdu, 6nnr - EcTS + deoxyuridine derivative

1f4c, 1f4e - EcTS + tosyl-proline derivative

1f4d - EcTS (mutant) + tosyl-proline derivative

1f4f, 1f4g - EcTS + glutamyl-proline derivative

3uwl – EfTS + 5-formyl tetrahydrofolate

5j7w – EfTS + drug

Thymidylate synthase ternary complex with UMP

1hvy, 1i00, 5x5q, 5x66, 5x67, 6zxo - hTS + drug + UMP

5hs3, 6pf6, 6pf5, 6pf4, 6pf3, 6ojv, 6oju - hTS + inhibitor + dUMP

1ju6, 1juj - hTS (mutant) + inhibitor + UMP

5fct - mTS + inhibitor + fluoro-UMP

4eb4, 6y08 - mTS + drug + UMP

6gko - mTS + phenolphthalein + UMP

1rts, 2tsr - TS + drug + UMP – rat

6k7s – sTS + UMP + drug

5noo - TS + drug + UMP – Caenorhabditis elegans

2tdd - LcTS + inhibitor + fluoro-UMP

1vzd - LcTS (mutant) + inhibitor + fluoro-UMP

1vze, 1tvu, 1tvv, 1tvw - LcTS (mutant) + inhibitor + UMP

1lca, 1lce, 3bnz - LcTS + inhibitor + UMP

3byx, 3bz0, 3c06, 3c0a, 3ijz, 3ik0, 3ik1 - LcTS + phthalimidic derivative + UMP

2bbq, 2tsc, 1kce, 1trg, 1kzi, 4isk, 4lrr, 1syn, 1tsd, 1jtq, 1jtu, 1jut, 1jg0, 2a9w - EcTS + inhibitor + UMP

1zpr, 1aiq, 1dna, 1bq1, 1kzj, 2vf0, 3b5b, 1nce - EcTS (mutant) + inhibitor + UMP

1tls, 1tsn - EcTS + inhibitor + fluoro-UMP

3bhl, 3bhr - EcTS + inhibitor + nitro-UMP

1bjg - EcTS (mutant) + inhibitor + fluoro-UMP

6cdz - EcTS (mutant) + deoxyuridine + UMP

2kce, 1axw - EcTS + drug + UMP

7jxf - EcTS + bi-substrate + UMP derivative

7jx1 - EcTS + bi-substrate + TMP

1ddu, 1tdu - EcTS + deoxyuridine derivative + inhibitor

6cdz - EcTS + deoxyuridine + UMP

4gev - EcTS + deoxyuridine derivative + cofactor analog

6nnr - EcTS + deoxyuridine derivative + folate derivative

1b02 - BsTS + inhibitor + fluoro-UMP

1ci7 - PcTS + inhibitor + UMP – Pneumocystis carinii

1f28 - PcTS + inhibitor + UMP

2aaz - TS + inhibitor + UMP – Filobasidiella neoformans

3qj7 - MtTS + spermine + UMP

4fog - MtTS + fluoro-UMP + methy-DHF

4fox, 4fqs - MtTS + inhibitor + fluoro-UMP

6qxs - EfTS + fluoro-dUMP + folate derivative

7cca, 7xyk - wssvTS + UMP + drug

5h3a – hhvORF70 + UMP + drug

7dp4, 7dp5 – BmaTS + UMP + drug

Thymidylate synthase ternary complex without UMP

1e2d, 1e2e, 1e2f - hTS (mutant) + ADP + TMP

6f6z - mTS + folate derivative + CMP derivative

4ez8 – mTS + substrate analog + dihydrofolate

5m4z - TwTS + folate derivative + CMP derivative

1lcb - LcTS + inhibitor + TMP

1tys - EcTS + inhibitor + TMP

2fto, 3bgx - EcTS (mutant) + inhibitor + TMP

1tlc - EcTS + inhibitor + GMP

4o7u - EfTS + phthalimidic derivative + folate derivative

Bifunctional dihydrofolate reductase-thymidylate synthase see Dihydrofolate reductase

Flavin-dependent thymidylate synthase ThyX

2af6, 3gwc - MtTS + FAD + halo-UMP

3hzg - MtTS + FAD

2gq2 - MtTS (mutant) + NADP

2cfa - TS + FAD – Paramecium bursaria chlorella virus

5jfe - TmTS + FAD + UMP – Thermotoga maritima

3g4a, 3g4c, 3n0b, 3n0c - TS (mutant) + FAD + UMP

1o24 – TmTS

1o25 – TmTS + UMP

1o2a – TmTS + FAD

4gtc, 4gtl, 4kar – TmTS (mutant) + FAD

1o26 – TmTS + FAD + UMP

4gtd, 4kas, 4kat, 5iot – TmTS (mutant) + FAD + UMP

1o27, 1o28, 1o29 – TmTS + FAD + halo-UMP

1o2b – TmTS + FAD + phosphate

4gta – TmTS + FAD + UMP + folate derivative

4gt9 – TmTS + FAD + UMP + folate

4gtf – TmTS (mutant) + FAD + UMP + folate

4gte – TmTS (mutant) + FAD + folate

4gtb – TmTS + FAD + UMP + drug

5chp – TmTS + FAD + UMP + inhibitor

5ioq, 5ior – TmTS + FAD + d-Uridine derivative

5ios, 2iot – TmTS (mutant) + FAD + dUMP

7ndw, 7ndz – TmTS + FAD derivative + pteridine derivative

3ge9 - CgTS

3fnn - CgTS + FAD

3ah5, 3n3y - TS + FAD + UMP – Helicobacter pylori

4p5a, 4p5b – TS + FAD + dUMP derivative – Streptomyces cacaoi

6j61 - TS + FAD – Thermus thermophilus