From Proteopedia

Sam's Killer DPPIV

spinqualitylabelsall models DPPIV bound to Vildagliptin Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image Contents 1 Introduction 1.1 Function 1.2 Inhibitors 2 Disease 3 Relevance 4 Structural highlights Introduction Function DPPIV with Vildagliptin PDB Inhibitors Figure 1. Catalytic triad of DPPIV with Vildagliptin Bound to active site (Catalytic water is shown in Red). Vildagliptin Inhibits DPPIV through a covalent bond to the Ser 608 of the catalytic triad.[1] Disease Relevance Structural highlights Structural over view highlighting the catalytic domain Scene representing all the Intxns Vildagliptin shares in the catalytic domain Structural over view highlighting/differentiating between the different domains of DPPIV An Intro movie or just a protein overview

References

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1. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
2. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
3. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677