Villin

From Proteopedia

Function Villin (VIL) is an actin-binding protein. It contains gelsolin-like domains in its N-terminal and a helical headpiece which binds actin[1]. Supervillin (SVIL) contains numerous gelsolin-like domains in its C-terminal and interacts with actin[2]. Advillin (AVIL) is another actin-binding protein in the gelsolin superfamily which is expressed in the peripheral sensory neurons. Cytovillin (CVIL) or ezrin or villin-2 serves as intermediate between plasma membrane and actin cytoskeleton[3]. Relevance VIL immunohisochemistry is a reliable method for diagnosing microvillus inclusion disease (MVID)[4].

spinqualitylabelsall models Human supervillin headpiece, 2k6n Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Villin

Updated on 11-January-2021

Supervillin

2k6m, 2k6n – hSVIL headpiece– human – NMR

Villin

3fg7 – hVIL-1 gelsolin domains 4-6

1unc – hVIL-1 headpiece

3iur - hVIL headpiece H2H3 helices + prolyl endopeptidase

1yu5, 1qqv - cVIL headpiece - chicken

2rjw, 2rjx, 2rjv, 2rjy, 1yu7, 1yu8, 3myc, 3mye, 3nkj, 3mya, 3tjw, 3trv, 3trw, 3try - cVIL-1 headpiece (mutant)

2llf - cVIL-1 gelsolin-like domain 6 - NMR

5i1n, 5i1o, 5i1p, 5i1s – cVIL-1 + cVIL headpiece

1vii, 2vik, 2vil, 4cz3, 4cz4 - cVIL-14T headpiece - NMR

2ppz, 2jm0 - VIL-1 headpiece (mutant) – synthetic – NMR

2f4k, 1wy3, 1wy4, 1yrf, 1yri - VIL-1 fragment (mutant) – synthetic

5vnt - VIL-4 C-terminal headpiece - Arabidopsis thaliana - NMR

Advillin

1und – hAVIL headpiece

Cytovillin or ezrin

1ni2 – hCVIL N terminal

4rm8, 4rm9 – hCVIL

4rma – hCVIL FERM domain

References

1. ↑ Friederich E, Vancompernolle K, Louvard D, Vandekerckhove J. Villin function in the organization of the actin cytoskeleton. Correlation of in vivo effects to its biochemical activities in vitro. J Biol Chem. 1999 Sep 17;274(38):26751-60. PMID:10480879
2. ↑ Smith TC, Fang Z, Luna EJ. Novel interactors and a role for supervillin in early cytokinesis. Cytoskeleton (Hoboken). 2010 Jun;67(6):346-64. doi: 10.1002/cm.20449. PMID:20309963 doi:http://dx.doi.org/10.1002/cm.20449
3. ↑ Turunen O, Wahlstrom T, Vaheri A. Ezrin has a COOH-terminal actin-binding site that is conserved in the ezrin protein family. J Cell Biol. 1994 Sep;126(6):1445-53. PMID:8089177
4. ↑ Shillingford NM, Calicchio ML, Teot LA, Boyd T, Kurek KC, Goldsmith JD, Bousvaros A, Perez-Atayde AR, Kozakewich HP. Villin immunohistochemistry is a reliable method for diagnosing microvillus inclusion disease. Am J Surg Pathol. 2015 Feb;39(2):245-50. doi: 10.1097/PAS.0000000000000355. PMID:25517957 doi:http://dx.doi.org/10.1097/PAS.0000000000000355