Structural highlights
Function
DLG3_RAT Required for learning most likely through its role in synaptic plasticity following NMDA receptor signaling (By similarity).
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
We report a general method for light-assisted control of interactions of PDZ domain binding motifs with their cognate domains by the incorporation of a photolabile caging group onto the essential C-terminal carboxylate binding determinant of the motif. The strategy was implemented and validated for both simple monovalent and biomimetic divalent ligands, which have recently been established as powerful tools for acute perturbation of native PDZ domain-dependent interactions in live cells.
Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions.,Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Sainlos M, Iskenderian-Epps WS, Olivier NB, Choquet D, Imperiali B. Caged mono- and divalent ligands for light-assisted disruption of PDZ domain-mediated interactions. J Am Chem Soc. 2013 Mar 27;135(12):4580-3. doi: 10.1021/ja309870q. Epub 2013 Mar , 13. PMID:23480637 doi:http://dx.doi.org/10.1021/ja309870q
