3tso

Structural highlights

Function

RAB25_HUMAN Involved in the regulation of cell survival. Promotes invasive migration of cells in which it functions to localize and maintain integrin alpha-V/beta-1 at the tips of extending pseudopodia. Increases the rates of ovarian and breast cancers progression and aggressiveness by modulating cellular processes such as proliferation, survival and migration of epithelial tumor cells. May selectively regulate the apical recycling pathway. Together with MYO5B regulates transcytosis (By similarity).^{[1] [2]}

See Also

• Ras-related protein Rab 3D structures

References

1. ↑ Cheng KW, Lahad JP, Kuo WL, Lapuk A, Yamada K, Auersperg N, Liu J, Smith-McCune K, Lu KH, Fishman D, Gray JW, Mills GB. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers. Nat Med. 2004 Nov;10(11):1251-6. Epub 2004 Oct 24. PMID:15502842 doi:http://dx.doi.org/10.1038/nm1125
2. ↑ Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Dev Cell. 2007 Oct;13(4):496-510. PMID:17925226 doi:http://dx.doi.org/10.1016/j.devcel.2007.08.012