5glg

Structural highlights

Function

OSM1_YEAST Irreversibly catalyzes the reduction of fumarate to succinate. Together with the second isozyme of soluble fumarate reductase (FRD1), essential for anaerobic growth. Involved in maintaining redox balance during oxygen deficiency conditions. Reduction of fumarate is the main source of succinate during fermentation, and under anaerobic conditions, the formation of succinate is strictly required for the reoxidation of FADH(2).^{[1] [2] [3] [4]}

References

1. ↑ Camarasa C, Grivet JP, Dequin S. Investigation by 13C-NMR and tricarboxylic acid (TCA) deletion mutant analysis of pathways for succinate formation in Saccharomyces cerevisiae during anaerobic fermentation. Microbiology. 2003 Sep;149(Pt 9):2669-78. PMID:12949191 doi:http://dx.doi.org/10.1099/mic.0.26007-0
2. ↑ Camarasa C, Faucet V, Dequin S. Role in anaerobiosis of the isoenzymes for Saccharomyces cerevisiae fumarate reductase encoded by OSM1 and FRDS1. Yeast. 2007 May;24(5):391-401. PMID:17345583 doi:http://dx.doi.org/10.1002/yea.1467
3. ↑ Muratsubaki H, Enomoto K. One of the fumarate reductase isoenzymes from Saccharomyces cerevisiae is encoded by the OSM1 gene. Arch Biochem Biophys. 1998 Apr 15;352(2):175-81. PMID:9587404 doi:http://dx.doi.org/10.1006/abbi.1998.0583
4. ↑ Arikawa Y, Enomoto K, Muratsubaki H, Okazaki M. Soluble fumarate reductase isoenzymes from Saccharomyces cerevisiae are required for anaerobic growth. FEMS Microbiol Lett. 1998 Aug 1;165(1):111-6. PMID:9711846