6pdm

Structural highlights

Function

ANM9_HUMAN Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA). Specifically mediates the symmetrical dimethylation of SF3B2. Involved in the regulation of alternative splicing of pre-mRNA (PubMed:25737013, PubMed:25979344).^{[1] [2]}

References

1. ↑ Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat Commun. 2015 Mar 4;6:6428. doi: 10.1038/ncomms7428. PMID:25737013 doi:http://dx.doi.org/10.1038/ncomms7428
2. ↑ Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem. 2015 Jul 3;290(27):16723-43. doi: 10.1074/jbc.M115.659433. Epub 2015, May 15. PMID:25979344 doi:http://dx.doi.org/10.1074/jbc.M115.659433