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7upn

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Maedi visna virus Vif in complex with CypA and E3 ubiquitin ligase

Structural highlights

7upn is a 8 chain structure with sequence from Homo sapiens and Visna-maedi virus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PPIA_HUMAN PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Publication Abstract from PubMed

Lentiviral Vif molecules target the host antiviral APOBEC3 proteins for destruction in cellular ubiquitin-proteasome pathways. Different lentiviral Vifs have evolved to use the same canonical E3 ubiquitin ligase complexes, along with distinct noncanonical host cofactors for their activities. Unlike primate lentiviral Vif, which recruits CBFbeta as the noncanonical cofactor, nonprimate lentiviral Vif proteins have developed different cofactor recruitment mechanisms. Maedi-visna virus (MVV) sequesters CypA as the noncanonical cofactor for the Vif-mediated ubiquitination of ovine APOBEC3s. Here, we report the cryo-electron microscopy structure of MVV Vif in complex with CypA and E3 ligase components. The structure, along with our biochemical and functional analysis, reveals both conserved and unique structural elements of MVV Vif and its common and distinct interaction modes with various cognate cellular proteins, providing a further understanding of the evolutionary relationship between lentiviral Vifs and the molecular mechanisms by which they capture different host cofactors for immune evasion activities.

Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif.,Hu Y, Gudnadottir RB, Knecht KM, Arizaga F, Jonsson SR, Xiong Y Sci Adv. 2023 Jan 13;9(2):eadd3422. doi: 10.1126/sciadv.add3422. Epub 2023 Jan , 13. PMID:36638173^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Hu Y, Gudnadottir RB, Knecht KM, Arizaga F, Jonsson SR, Xiong Y. Structural basis for recruitment of host CypA and E3 ubiquitin ligase by maedi-visna virus Vif. Sci Adv. 2023 Jan 13;9(2):eadd3422. doi: 10.1126/sciadv.add3422. Epub 2023 Jan , 13. PMID:36638173 doi:http://dx.doi.org/10.1126/sciadv.add3422