Structural highlights
Function
CDDTR_MYCTU May have transcription regulation and metal-detoxifying functions through which it may enhance intracellular survival of mycobacteria. Binds to its own promoter region and to the Rv1999c promoter region. It displays strong affinity for cadmium ions, but can also bind zinc, manganese and nickel. Expression increases the intracellular survival of recombinant M. smegmatis in murine macrophage cell line and increases its tolerance to cadmium ions.[1]
References
- ↑ Kumari M, Pal RK, Mishra AK, Tripathi S, Biswal BK, Srivastava KK, Arora A. Structural and functional characterization of the transcriptional regulator Rv3488 of Mycobacterium tuberculosis H37Rv. Biochem J. 2018 Nov 9;475(21):3393-3416. doi: 10.1042/BCJ20180356. PMID:30266832 doi:http://dx.doi.org/10.1042/BCJ20180356
