7y1b

Structural highlights

Function

BASI_MOUSE Essential for normal retinal maturation and development (PubMed:10967074, PubMed:11273674, PubMed:11853760). Acts as a retinal cell surface receptor for NXNL1 and plays an important role in NXNL1-mediated survival of retinal cone photoreceptors (PubMed:25957687). In association with glucose transporter SLC16A1/GLUT1 and NXNL1, promotes retinal cone survival by enhancing aerobic glycolysis and accelerating the entry of glucose into photoreceptors (PubMed:25957687).^{[1] [2] [3] [4]} Signaling receptor for cyclophilins, essential for PPIA/CYPA and PPIB/CYPB-dependent signaling related to chemotaxis and adhesion of immune cells (By similarity). Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane (PubMed:12601063). Acts as a coreceptor for vascular endothelial growth factor receptor 2 (KDR/VEGFR2) in endothelial cells enhancing its VEGFA-mediated activation and downstream signaling (By similarity). Promotes angiogenesis through EPAS1/HIF2A-mediated up-regulation of VEGFA and KDR/VEGFR2 in endothelial cells (By similarity). Plays an important role in spermatogenesis; mediates interactions between germ cells and Sertoli cell and is essential for the development/differentiation of germ cells to round spermatids (PubMed:23727514, PubMed:11882021).[UniProtKB:P35613]^{[5] [6] [7]}

References

1. ↑ Hori K, Katayama N, Kachi S, Kondo M, Kadomatsu K, Usukura J, Muramatsu T, Mori S, Miyake Y. Retinal dysfunction in basigin deficiency. Invest Ophthalmol Vis Sci. 2000 Sep;41(10):3128-33 PMID:10967074
2. ↑ Ochrietor JD, Moroz TM, Kadomatsu K, Muramatsu T, Linser PJ. Retinal degeneration following failed photoreceptor maturation in 5A11/basigin null mice. Exp Eye Res. 2001 Apr;72(4):467-77. PMID:11273674 doi:10.1006/exer.2000.0974
3. ↑ Ochrietor JD, Moroz TP, Clamp MF, Timmers AM, Muramatsu T, Linser PJ. Inactivation of the Basigin gene impairs normal retinal development and maturation. Vision Res. 2002 Feb;42(4):447-53. PMID:11853760 doi:10.1016/s0042-6989(01)00236-x
4. ↑ Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, Dalkara D, van Dorsselaer A, Sahel JA, Léveillard T. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 2015 May 7;161(4):817-32. PMID:25957687 doi:10.1016/j.cell.2015.03.023
5. ↑ Saxena DK, Oh-Oka T, Kadomatsu K, Muramatsu T, Toshimori K. Behaviour of a sperm surface transmembrane glycoprotein basigin during epididymal maturation and its role in fertilization in mice. Reproduction. 2002 Mar;123(3):435-44. PMID:11882021 doi:10.1530/rep.0.1230435
6. ↑ Philp NJ, Ochrietor JD, Rudoy C, Muramatsu T, Linser PJ. Loss of MCT1, MCT3, and MCT4 expression in the retinal pigment epithelium and neural retina of the 5A11/basigin-null mouse. Invest Ophthalmol Vis Sci. 2003 Mar;44(3):1305-11. PMID:12601063 doi:10.1167/iovs.02-0552
7. ↑ Bi J, Li Y, Sun F, Saalbach A, Klein C, Miller DJ, Hess R, Nowak RA. Basigin null mutant male mice are sterile and exhibit impaired interactions between germ cells and Sertoli cells. Dev Biol. 2013 Aug 15;380(2):145-56. PMID:23727514 doi:10.1016/j.ydbio.2013.05.023