Structural highlights
Function
RIR2B_MYCTU Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Two genes for this protein are present in M.tuberculosis; this is the active form. When coexpressed in E.coli with nrdE the 2 proteins complement a temperature-sensitive E.coli mutant.[1]
References
- ↑ Yang F, Curran SC, Li LS, Avarbock D, Graf JD, Chua MM, Lu G, Salem J, Rubin H. Characterization of two genes encoding the Mycobacterium tuberculosis ribonucleotide reductase small subunit. J Bacteriol. 1997 Oct;179(20):6408-15. PMID:9335290 doi:10.1128/jb.179.20.6408-6415.1997
