Structural highlights
Disease
ZBT18_HUMAN Distal deletion 1q. The disease is caused by variants affecting the gene represented in this entry.
Function
ZBT18_HUMAN Transcriptional repressor that plays a role in various developmental processes such as myogenesis and brain development. Plays a key role in myogenesis by directly repressing the expression of ID2 and ID3, 2 inhibitors of skeletal myogenesis. Also involved in controlling cell division of progenitor cells and regulating the survival of postmitotic cortical neurons. Specifically binds the consensus DNA sequence 5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by recruiting chromatin remodeling multiprotein complexes. May also play a role in the organization of chromosomes in the nucleus.[1]
References
- ↑ Aoki K, Meng G, Suzuki K, Takashi T, Kameoka Y, Nakahara K, Ishida R, Kasai M. RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression. J Biol Chem. 1998 Oct 9;273(41):26698-704. PMID:9756912 doi:10.1074/jbc.273.41.26698
