Structural highlights
Function
GP_CCHFI Glycoprotein C and glycoprotein N interact with each other and are present at the surface of the virion. They are able to attach the virion to host cell receptors. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Also promotes fusion of viral membrane with host endosomal membrane after endocytosis of the virion (By similarity).[1]
References
- ↑ Simon M, Johansson C, Mirazimi A. Crimean-Congo hemorrhagic fever virus entry and replication is clathrin-, pH- and cholesterol-dependent. J Gen Virol. 2009 Jan;90(Pt 1):210-5. doi: 10.1099/vir.0.006387-0. PMID:19088291 doi:http://dx.doi.org/10.1099/vir.0.006387-0
