| Structural highlights
Function
AGRG2_MOUSE Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA; also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione (PubMed:35982227). Involved in a signal transduction pathway controlling epididymal function and male fertility (PubMed:15367682). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase (PubMed:35982227). ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity (PubMed:35982227). Also able to couple with G(q) G proteins in vitro (PubMed:35982227). May regulate fluid exchange within epididymis (PubMed:15367682).[1] [2]
References
- ↑ Davies B, Baumann C, Kirchhoff C, Ivell R, Nubbemeyer R, Habenicht UF, Theuring F, Gottwald U. Targeted deletion of the epididymal receptor HE6 results in fluid dysregulation and male infertility. Mol Cell Biol. 2004 Oct;24(19):8642-8. PMID:15367682 doi:10.1128/MCB.24.19.8642-8648.2004
- ↑ Lin H, Xiao P, Bu RQ, Guo S, Yang Z, Yuan D, Zhu ZL, Zhang CX, He QT, Zhang C, Ping YQ, Zhao RJ, Ma CS, Liu CH, Zhang XN, Jiang D, Huang S, Xi YT, Zhang DL, Xue CY, Yang BS, Li JY, Lin HC, Zeng XH, Zhao H, Xu WM, Yi F, Liu Z, Sun JP, Yu X. Structures of the ADGRG2-G(s) complex in apo and ligand-bound forms. Nat Chem Biol. 2022 Nov;18(11):1196-1203. PMID:35982227 doi:10.1038/s41589-022-01084-6
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