| Structural highlights
Function
MMPL5_MYCTU Part of an export system, which is required for biosynthesis and secretion of siderophores.[1] Overexpression of the system confers non-target based resistance to azoles, clofazimine and bedaquiline, via an efflux mechanism.[2] [3] [4]
References
- ↑ Wells RM, Jones CM, Xi Z, Speer A, Danilchanka O, Doornbos KS, Sun P, Wu F, Tian C, Niederweis M. Discovery of a Siderophore Export System Essential for Virulence of Mycobacterium tuberculosis. PLoS Pathog. 2013 Jan;9(1):e1003120. doi: 10.1371/journal.ppat.1003120. Epub 2013, Jan 31. PMID:23431276 doi:http://dx.doi.org/10.1371/journal.ppat.1003120
- ↑ Milano A, Pasca MR, Provvedi R, Lucarelli AP, Manina G, Ribeiro AL, Manganelli R, Riccardi G. Azole resistance in Mycobacterium tuberculosis is mediated by the MmpS5-MmpL5 efflux system. Tuberculosis (Edinb). 2009 Jan;89(1):84-90. doi: 10.1016/j.tube.2008.08.003. Epub , 2008 Oct 11. PMID:18851927 doi:http://dx.doi.org/10.1016/j.tube.2008.08.003
- ↑ Hartkoorn RC, Uplekar S, Cole ST. Cross-resistance between clofazimine and bedaquiline through upregulation of MmpL5 in Mycobacterium tuberculosis. Antimicrob Agents Chemother. 2014 May;58(5):2979-81. doi: 10.1128/AAC.00037-14. , Epub 2014 Mar 3. PMID:24590481 doi:http://dx.doi.org/10.1128/AAC.00037-14
- ↑ Andries K, Villellas C, Coeck N, Thys K, Gevers T, Vranckx L, Lounis N, de Jong BC, Koul A. Acquired resistance of Mycobacterium tuberculosis to bedaquiline. PLoS One. 2014 Jul 10;9(7):e102135. PMID:25010492 doi:10.1371/journal.pone.0102135
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