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9ca9

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Cryo-EM structure of the human SRCAP complex in the unbound state (composite structure)

Structural highlights

9ca9 is a 10 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.56Å
Ligands:	, , ,
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

SRCAP_HUMAN Floating-Harbor syndrome. The disease is caused by mutations affecting the gene represented in this entry.

Function

SRCAP_HUMAN Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription.^[1] ^[2] ^[3] ^[4] ^[5] ^[6]

References

↑ Johnston H, Kneer J, Chackalaparampil I, Yaciuk P, Chrivia J. Identification of a novel SNF2/SWI2 protein family member, SRCAP, which interacts with CREB-binding protein. J Biol Chem. 1999 Jun 4;274(23):16370-6. doi: 10.1074/jbc.274.23.16370. PMID:10347196 doi:http://dx.doi.org/10.1074/jbc.274.23.16370
↑ Monroy MA, Ruhl DD, Xu X, Granner DK, Yaciuk P, Chrivia JC. Regulation of cAMP-responsive element-binding protein-mediated transcription by the SNF2/SWI-related protein, SRCAP. J Biol Chem. 2001 Nov 2;276(44):40721-6. Epub 2001 Aug 24. PMID:11522779 doi:http://dx.doi.org/10.1074/jbc.M103615200
↑ Monroy MA, Schott NM, Cox L, Chen JD, Ruh M, Chrivia JC. SNF2-related CBP activator protein (SRCAP) functions as a coactivator of steroid receptor-mediated transcription through synergistic interactions with CARM-1 and GRIP-1. Mol Endocrinol. 2003 Dec;17(12):2519-28. Epub 2003 Sep 18. PMID:14500758 doi:http://dx.doi.org/10.1210/me.2003-0208
↑ Eissenberg JC, Wong M, Chrivia JC. Human SRCAP and Drosophila melanogaster DOM are homologs that function in the notch signaling pathway. Mol Cell Biol. 2005 Aug;25(15):6559-69. doi: 10.1128/MCB.25.15.6559-6569.2005. PMID:16024792 doi:http://dx.doi.org/10.1128/MCB.25.15.6559-6569.2005
↑ Ruhl DD, Jin J, Cai Y, Swanson S, Florens L, Washburn MP, Conaway RC, Conaway JW, Chrivia JC. Purification of a human SRCAP complex that remodels chromatin by incorporating the histone variant H2A.Z into nucleosomes. Biochemistry. 2006 May 2;45(17):5671-7. PMID:16634648 doi:http://dx.doi.org/10.1021/bi060043d
↑ Wong MM, Cox LK, Chrivia JC. The chromatin remodeling protein, SRCAP, is critical for deposition of the histone variant H2A.Z at promoters. J Biol Chem. 2007 Sep 7;282(36):26132-9. Epub 2007 Jul 8. PMID:17617668 doi:http://dx.doi.org/M703418200