| Structural highlights
Function
S35B1_HUMAN ATP:ADP antiporter that catalyzes the exchange of ATP and ADP across the endoplasmic reticulum (ER) membrane. Imports ATP from the cytosol to the ER lumen and exports ADP in the opposite direction (PubMed:30154480, PubMed:35041824). Regulates ER energy metabolism and protein biogenesis. Appears to be part of a calcium-dependent ER to cytosol low energy response axis, where calcium efflux from ER to the cytosol triggers ATP import into the ER lumen to maintain sufficient ATP supply. Provides ATP to ER chaperone HSPA5 that drives protein folding and trafficking in the ER (PubMed:30154480, PubMed:35041824). Can transport dATP, UTP or UDP in exchange for ATP, but the physiological relevance of this process remains to be established (PubMed:30154480, PubMed:35041824).[1] [2] ATP:ADP antiporter.[3] [4] ATP:ADP antiporter.[5]
References
- ↑ Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I. AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum. Nat Commun. 2018 Aug 28;9(1):3489. PMID:30154480 doi:10.1038/s41467-018-06003-9
- ↑ Schwarzbaum PJ, Schachter J, Bredeston LM. The broad range di affinities for ATP transport across the ER membrane. J Biol Chem. 2022 Apr;298(4):101537. PMID:35041824 doi:10.1016/j.jbc.2021.101537
- ↑ Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I. AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum. Nat Commun. 2018 Aug 28;9(1):3489. PMID:30154480 doi:10.1038/s41467-018-06003-9
- ↑ Schwarzbaum PJ, Schachter J, Bredeston LM. The broad range di affinities for ATP transport across the ER membrane. J Biol Chem. 2022 Apr;298(4):101537. PMID:35041824 doi:10.1016/j.jbc.2021.101537
- ↑ Klein MC, Zimmermann K, Schorr S, Landini M, Klemens PAW, Altensell J, Jung M, Krause E, Nguyen D, Helms V, Rettig J, Fecher-Trost C, Cavalié A, Hoth M, Bogeski I, Neuhaus HE, Zimmermann R, Lang S, Haferkamp I. AXER is an ATP/ADP exchanger in the membrane of the endoplasmic reticulum. Nat Commun. 2018 Aug 28;9(1):3489. PMID:30154480 doi:10.1038/s41467-018-06003-9
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