Function 
Poly (ADP-ribose) glycohydrolase (PARG) hydrolizes the ribose-ribose bonds in poly (ADP-ribose).  Poly (ADP-ribose) are synthesized after DNA damage.  PARG acts as both endo- and exoglycosidase and releases poly (ADP-ribose) of different lengths including monomers[1].
  Relevance 
PARG deficiency leads to cell death.  Over-activation of PARP due to oxidative stress culminates in cell dysfunction and necrosis.  PARP inhibitors have anti-inflammatory effect[2].
  Structural highlights 
The  of PARG contains [3]. Water molecules are shown as red spheres.
  3D Structures of poly (ADP-ribose) glycohydrolase 
Poly(ADP-ribose) glycohydrolase 3D structures