User:Eran Hodis/Sandbox5

From Proteopedia

TPI catalyzes the transfer of a hydrogen atom from carbon 1 to carbon 2, an intramolecular reaction^[1]. This isomerization of a ketose to an aldose proceeds through an cis-enediol(ate) intermediate. This isomerization proceeds without any cofactors and the enzyme confers a 10⁹ rate enhancement relative to the nonenzymatic reaction involving a chemical base (acetate ion).^[2]

References

1. ↑ http://en.wikipedia.org/wiki/Oxidation_reduction
2. ↑ Davenport RC, Bash PA, Seaton BA, Karplus M, Petsko GA, Ringe D. Structure of the triosephosphate isomerase-phosphoglycolohydroxamate complex: an analogue of the intermediate on the reaction pathway. Biochemistry. 1991 Jun 18;30(24):5821-6. PMID:2043623