Structural highlights
Function
LACB_BOVIN Primary component of whey, it binds retinol and is probably involved in the transport of that molecule.
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
Publication Abstract from PubMed
The X-ray structure of bovine beta-lactoglobulin with the ligand 12-bromododecanoic acid as a model for fatty acids has been determined at a resolution of 2.23 A in the trigonal lattice Z form. The ligand binds inside the calyx, resolving a long-standing controversy as to where fatty-acid like ligands bind. The carboxylate head group lies at the surface of the molecule, and the lid to the calyx is open at the pH of crystallization (pH 7.3), consistent with the conformation observed in ligand-free bovine beta-lactoglobulin in lattice Z at pH 7.1 and pH 8.2.
12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin.,Qin BY, Creamer LK, Baker EN, Jameson GB FEBS Lett. 1998 Nov 6;438(3):272-8. PMID:9827560[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
See Also
References
- ↑ Qin BY, Creamer LK, Baker EN, Jameson GB. 12-Bromododecanoic acid binds inside the calyx of bovine beta-lactoglobulin. FEBS Lett. 1998 Nov 6;438(3):272-8. PMID:9827560
