1esc

From Proteopedia

THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES

Structural highlights

1esc is a 1 chain structure with sequence from Streptomyces scabiei. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	X-ray diffraction, Resolution 2.1Å
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

ESTA_STRSC

Evolutionary Conservation

Checkto colour the structure by Evolutionary Conservation, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

Publication Abstract from PubMed

The crystal structure of a novel esterase from Streptomyces scabies, a causal agent of the potato scab disease, was solved at 2.1 A resolution. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases. The active site contains a dyad of Ser 14 and His 283, closely resembling two of the three components of typical Ser-His-Asp(Glu) triads from other serine hydrolases. Proper orientation of the active site imidazol is maintained by a hydrogen bond between the N delta-H group and a main chain oxygen. Thus, the enzyme constitutes the first known natural variation of the chymotrypsin-like triad in which a carboxylic acid is replaced by a neutral hydrogen-bond acceptor.

A novel variant of the catalytic triad in the Streptomyces scabies esterase.,Wei Y, Schottel JL, Derewenda U, Swenson L, Patkar S, Derewenda ZS Nat Struct Biol. 1995 Mar;2(3):218-23. PMID:7773790^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

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Citations

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References

↑ Wei Y, Schottel JL, Derewenda U, Swenson L, Patkar S, Derewenda ZS. A novel variant of the catalytic triad in the Streptomyces scabies esterase. Nat Struct Biol. 1995 Mar;2(3):218-23. PMID:7773790

1 Structural highlights
2 Function
3 Evolutionary Conservation
4 Publication Abstract from PubMed
5 References

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PDB ID 1esc

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1esc

From Proteopedia

THE MOLECULAR MECHANISM OF ENANTIORECOGNITION BY ESTERASES

Structural highlights

Function

Evolutionary Conservation

Publication Abstract from PubMed

References

Contents

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