1tee

Structural highlights

Function

PKS18_MYCTU Involved in the biosynthesis of tri- and tetraketide alpha-pyrones. Pks18 catalyzes the extension of medium- and long-chain aliphatic acyl-CoA substrates by using malonyl-CoA as an extender molecule to synthesize polyketide products.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Saxena P, Yadav G, Mohanty D, Gokhale RS. A new family of type III polyketide synthases in Mycobacterium tuberculosis. J Biol Chem. 2003 Nov 7;278(45):44780-90. PMID:12941968 doi:10.1074/jbc.M306714200
2. ↑ Sankaranarayanan R, Saxena P, Marathe UB, Gokhale RS, Shanmugam VM, Rukmini R. A novel tunnel in mycobacterial type III polyketide synthase reveals the structural basis for generating diverse metabolites. Nat Struct Mol Biol. 2004 Sep;11(9):894-900. Epub 2004 Aug 1. PMID:15286723 doi:10.1038/nsmb809
3. ↑ Arora P, Vats A, Saxena P, Mohanty D, Gokhale RS. Promiscuous fatty acyl CoA ligases produce acyl-CoA and acyl-SNAC precursors for polyketide biosynthesis. J Am Chem Soc. 2005 Jul 6;127(26):9388-9. PMID:15984864 doi:10.1021/ja052991s