1umg

Structural highlights

Function

FBPAP_SULTO Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• Fructose-1%2C6-bisphosphatase 3D structures

References

1. ↑ Nishimasu H, Fushinobu S, Shoun H, Wakagi T. The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea. Structure. 2004 Jun;12(6):949-59. PMID:15274916 doi:10.1016/j.str.2004.03.026
2. ↑ Say RF, Fuchs G. Fructose 1,6-bisphosphate aldolase/phosphatase may be an ancestral gluconeogenic enzyme. Nature. 2010 Apr 15;464(7291):1077-81. PMID:20348906 doi:10.1038/nature08884
3. ↑ Fushinobu S, Nishimasu H, Hattori D, Song HJ, Wakagi T. Structural basis for the bifunctionality of fructose-1,6-bisphosphate aldolase/phosphatase. Nature. 2011 Oct 9;478(7370):538-41. doi: 10.1038/nature10457. PMID:21983966 doi:10.1038/nature10457
4. ↑ Nishimasu H, Fushinobu S, Shoun H, Wakagi T. The first crystal structure of the novel class of fructose-1,6-bisphosphatase present in thermophilic archaea. Structure. 2004 Jun;12(6):949-59. PMID:15274916 doi:10.1016/j.str.2004.03.026