1vk2

Structural highlights

Function

UDGA_THEMA Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

• DNA glycosylase 3D structures

References

1. ↑ Sandigursky M, Franklin WA. Thermostable uracil-DNA glycosylase from Thermotoga maritima a member of a novel class of DNA repair enzymes. Curr Biol. 1999 May 20;9(10):531-4. doi: 10.1016/s0960-9822(99)80237-1. PMID:10339434 doi:http://dx.doi.org/10.1016/s0960-9822(99)80237-1
2. ↑ Sandigursky M, Faje A, Franklin WA. Characterization of the full length uracil-DNA glycosylase in the extreme thermophile Thermotoga maritima. Mutat Res. 2001 Apr 4;485(3):187-95. doi: 10.1016/s0921-8777(00)00083-5. PMID:11267830 doi:http://dx.doi.org/10.1016/s0921-8777(00)00083-5