Structural highlights
Publication Abstract from PubMed
The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.
Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs.,Coll M, Wang AH, van der Marel GA, van Boom JH, Rich A J Biomol Struct Dyn. 1986 Oct;4(2):157-72. doi: 10.1080/07391102.1986.10506337. PMID:3271437[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Coll M, Wang AH, van der Marel GA, van Boom JH, Rich A. Crystal structure of a Z-DNA fragment containing thymine/2-aminoadenine base pairs. J Biomol Struct Dyn. 1986 Oct;4(2):157-72. doi: 10.1080/07391102.1986.10506337. PMID:3271437 doi:http://dx.doi.org/10.1080/07391102.1986.10506337
