1xs8

Structural highlights

Function

FETP_SALTY Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes. Necessary to maintain high levels of aconitase under oxidative stress.^{[1] [2] [3]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Gralnick J, Downs D. Protection from superoxide damage associated with an increased level of the YggX protein in Salmonella enterica. Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):8030-5. Epub 2001 Jun 19. PMID:11416172 doi:http://dx.doi.org/10.1073/pnas.151243198
2. ↑ Gralnick JA, Downs DM. The YggX protein of Salmonella enterica is involved in Fe(II) trafficking and minimizes the DNA damage caused by hydroxyl radicals: residue CYS-7 is essential for YggX function. J Biol Chem. 2003 Jun 6;278(23):20708-15. Epub 2003 Mar 31. PMID:12670952 doi:http://dx.doi.org/10.1074/jbc.M301577200
3. ↑ Skovran E, Lauhon CT, Downs DM. Lack of YggX results in chronic oxidative stress and uncovers subtle defects in Fe-S cluster metabolism in Salmonella enterica. J Bacteriol. 2004 Nov;186(22):7626-34. PMID:15516576 doi:http://dx.doi.org/10.1128/JB.186.22.7626-7634.2004