Structural highlights
Function
CMOJ_BACSU Involved in a cysteine salvage pathway from S-alkylcysteine. Catalyzes the C-S bond cleavage in N-acetyl-S-benzyl-L-cysteine sulfoxide leading to N-acetyl-S-hydroxy-L-cysteine and benzaldehyde. This pathway is likely important in the catabolism of alkylated cysteine generated by proteolysis of alkylated glutathione formed in the detoxification of a wide range of electrophiles. Has much less efficient activity with N-acetyl-S-methyl-L-cysteine sulfoxide as substrate. Cannot use S-alkylated L-cysteine sulfones and ketone analogs as substrates, demonstrating that the sulfoxide is required for activity.[1]
Evolutionary Conservation
Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.
References
- ↑ Hazra S, Bhandari DM, Krishnamoorthy K, Sekowska A, Danchin A, Begley TP. Cysteine Dealkylation in Bacillus subtilis by a Novel Flavin-Dependent Monooxygenase. Biochemistry. 2022 Jun 7;61(11):952-955. PMID:35584544 doi:10.1021/acs.biochem.2c00020
