2fm9

Structural highlights

Function

SIPA_SALTY Actin-binding protein that interferes with host cell actin cytoskeleton. It stimulates actin polymerization and counteracts F-actin destabilizing proteins. Potentiates SipC activity; both are required for an efficient bacterial internalization. In vitro, forms a complex with host cell protein T-plastin increasing actin bundling. It inhibits ADF/cofilin-directed depolymerization both by preventing binding of ADF and cofilin and by displacing them from F-actin. Also protects F-actin from gelsolin-directed severing and reanneals gelsolin-severed F-actin fragments.^{[1] [2]}

References

1. ↑ Zhou D, Mooseker MS, Galan JE. Role of the S. typhimurium actin-binding protein SipA in bacterial internalization. Science. 1999 Mar 26;283(5410):2092-5. PMID:10092234
2. ↑ McGhie EJ, Hayward RD, Koronakis V. Control of actin turnover by a salmonella invasion protein. Mol Cell. 2004 Feb 27;13(4):497-510. PMID:14992720