2l2l

Structural highlights

Function

P66A_HUMAN Transcriptional repressor. Enhances MBD2-mediated repression. Efficient repression requires the presence of GATAD2B.^{[1] [2]}

See Also

• Methyl CpG binding protein 3D structures

References

1. ↑ Brackertz M, Boeke J, Zhang R, Renkawitz R. Two highly related p66 proteins comprise a new family of potent transcriptional repressors interacting with MBD2 and MBD3. J Biol Chem. 2002 Oct 25;277(43):40958-66. Epub 2002 Aug 14. PMID:12183469 doi:http://dx.doi.org/10.1074/jbc.M207467200
2. ↑ Brackertz M, Gong Z, Leers J, Renkawitz R. p66alpha and p66beta of the Mi-2/NuRD complex mediate MBD2 and histone interaction. Nucleic Acids Res. 2006 Jan 13;34(2):397-406. Print 2006. PMID:16415179 doi:http://dx.doi.org/10.1093/nar/gkj437