Structural highlights
Function
HDG_METAC Excises hypoxanthine, a deamination product of adenine, from double-stranded DNA. Acts on double-stranded DNA containing G/I, T/I, A/I and C/I base pairs, but not on single-stranded inosine-containing DNA. Has also minor xanthine DNA glycosylase activity. Lacks any detectable uracil-DNA glycosylase activity.[1]
References
- ↑ Lee HW, Dominy BN, Cao W. New family of deamination repair enzymes in uracil-DNA glycosylase superfamily. J Biol Chem. 2011 Sep 9;286(36):31282-7. doi: 10.1074/jbc.M111.249524. Epub 2011 , Jun 3. PMID:21642431 doi:http://dx.doi.org/10.1074/jbc.M111.249524
