2mxz

Structural highlights

Function

ENLYS_BPT5 Endolysin with L-alanyl-D-glutamate peptidase activity that degrades host peptidoglycans and participates with the holin in the sequential events which lead to the programmed host cell lysis releasing the mature viral particles. Once the holin has permeabilized the host cell membrane, the endolysin can reach the periplasm and break down the peptidoglycan layer by hydrolyzing the link between L-alanine and D-glutamate residues.^[1]

References

1. ↑ Mikoulinskaia GV, Odinokova IV, Zimin AA, Lysanskaya VY, Feofanov SA, Stepnaya OA. Identification and characterization of the metal ion-dependent L-alanoyl-D-glutamate peptidase encoded by bacteriophage T5. FEBS J. 2009 Dec;276(24):7329-42. PMID:19919545 doi:10.1111/j.1742-4658.2009.07443.x