Structural highlights
Publication Abstract from PubMed
AGRO100 (also known as AS1411) is a G-rich oligonucleotide that has long been established as a potent anti-cancer aptamer. However, the structure of AGRO100 remained unresolved, due to the co-existence of multiple different G-quadruplex conformations. We identified a DNA sequence named AT11, derived from AGRO100, which formed a single major G-quadruplex conformation and exhibited a similar anti-proliferative activity as AGRO100. The solution structure of AT11 revealed a four-layer G-quadruplex comprising of two propeller-type parallel-stranded subunits connected through a central linker. The stacking between the two subunits occurs at the 3Î-end of the first block and the 5Î-end of the second block. The structure of the anti-proliferative DNA sequence AT11 will allow greater understanding on the G-quadruplex folding principles and aid in structural optimization of anti-proliferative oligonucleotides.
G-quadruplex structure of an anti-proliferative DNA sequence.,Do NQ, Chung WJ, Truong THA, Heddi B, Phan AT Nucleic Acids Res. 2017 Jul 7;45(12):7487-7493. doi: 10.1093/nar/gkx274. PMID:28549181[1]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Do NQ, Chung WJ, Truong THA, Heddi B, Phan AT. G-quadruplex structure of an anti-proliferative DNA sequence. Nucleic Acids Res. 2017 Jul 7;45(12):7487-7493. PMID:28549181 doi:10.1093/nar/gkx274
