2vn8

Structural highlights

Disease

RT4I1_HUMAN Autosomal recessive isolated optic atrophy. The disease is caused by variants affecting the gene represented in this entry.

Function

RT4I1_HUMAN Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.[UniProtKB:Q924D0]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.