2ymw

Structural highlights

Function

LODA_MARM1 Has antibacterial activity against a wide spectrum of Gram-positive and Gram-negative bacteria including nosocomial isolates of S.aureus and Pseudomonas sp. The antimicrobial activity is due to hydrogen peroxide generated by its lysine oxidase activity. Also has autotoxic activity. Involved in biofilm differentiation; responsible for cell death within microcolonies during biofilm development which is linked to the generation of a phenotypically diverse dispersal population and thus may play a role in colonization.^{[1] [2] [3]}

References

1. ↑ Lucas-Elio P, Hernandez P, Sanchez-Amat A, Solano F. Purification and partial characterization of marinocine, a new broad-spectrum antibacterial protein produced by Marinomonas mediterranea. Biochim Biophys Acta. 2005 Jan 18;1721(1-3):193-203. Epub 2004 Nov 26. PMID:15652194 doi:http://dx.doi.org/10.1016/j.bbagen.2004.11.002
2. ↑ Mai-Prochnow A, Lucas-Elio P, Egan S, Thomas T, Webb JS, Sanchez-Amat A, Kjelleberg S. Hydrogen peroxide linked to lysine oxidase activity facilitates biofilm differentiation and dispersal in several gram-negative bacteria. J Bacteriol. 2008 Aug;190(15):5493-501. doi: 10.1128/JB.00549-08. Epub 2008 May, 23. PMID:18502869 doi:http://dx.doi.org/10.1128/JB.00549-08
3. ↑ Gomez D, Lucas-Elio P, Solano F, Sanchez-Amat A. Both genes in the Marinomonas mediterranea lodAB operon are required for the expression of the antimicrobial protein lysine oxidase. Mol Microbiol. 2010 Jan;75(2):462-73. doi: 10.1111/j.1365-2958.2009.07000.x. Epub, 2009 Dec 16. PMID:20025674 doi:http://dx.doi.org/10.1111/j.1365-2958.2009.07000.x