2z1z

Structural highlights

Function

DAPAT_ARATH Required for lysine biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate, a reaction that requires three enzymes in E.coli. Not active with meso-diaminopimelate, lysine or ornithine as substrates.^{[1] [2]}

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

1. ↑ Hudson AO, Singh BK, Leustek T, Gilvarg C. An LL-diaminopimelate aminotransferase defines a novel variant of the lysine biosynthesis pathway in plants. Plant Physiol. 2006 Jan;140(1):292-301. Epub 2005 Dec 16. PMID:16361515 doi:http://dx.doi.org/pp.105.072629
2. ↑ Watanabe N, James MN. Structural insights for the substrate recognition mechanism of LL-diaminopimelate aminotransferase. Biochim Biophys Acta. 2011 Nov;1814(11):1528-33. doi:, 10.1016/j.bbapap.2011.03.008. Epub 2011 Mar 22. PMID:21435399 doi:http://dx.doi.org/10.1016/j.bbapap.2011.03.008