The 3-Hydroxypropionate bicycle, also known as the 3-Hydroxypropionate pathway, is a process that allows some bacteria to generate 3-Hydroxypropionate utilizing carbon dioxide. In this pathway CO2 is fixed (i.e. incorporated) by the action of two enzymes, acetyl-CoA carboxylase and propionyl-CoA carboxylase. See also Carbon Fixation.
These enzymes generate and , respectively. Malonyl-CoA, in a series of reactions is further split into and . Glyoxylate is incorporated into beta-methylmalyl-CoA which is then split, again through a series of reactions to release pyruvate as well as acetate, which is used to replenish the cycle.
